downregulation of il-12 production in healthy non-responder neonates to recombinant hepatitis b vaccine
نویسندگان
چکیده
a proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis b (hb) vaccine. unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. in this study, il-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group of responder and non-responder neonates. our results indicate significantly decreased production of hbsag-induced il-12 in non-responder subjects compared to responders (p<0.01). since il-12 is produced mainly by antigen presenting cells (apc) and is considered to be crucial for initiation and polarization of cd4+ t-cell function, therefore, our findings could be interpreted to imply apc dysfunction in non-responder vaccinees
منابع مشابه
Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine
A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group ...
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عنوان ژورنال:
iranian biomedical journalجلد ۸، شماره ۱، صفحات ۴۱-۴۵
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